Overweight and obesity is a major public health concern of today’s era and become a global pandemic now. The present study aimed to compute changes in biomarkers of weight gain via hypocaloric diet suggested with dairy food products. In order to investigate effect of intervention study 32 cases and 12 controls were selected from different faculties and institutes of Banaras Hindu University, Varanasi. The respondents were selected by purposive sampling technique and the tools used for data collection was interview schedule. Assessment of anthropometric, clinical, biochemical, proinflammatory and anti-inflammatory biomarkers was done before and after intervention i.e. of 6 months. The result showed that there was significant difference observed between case and control group after 6 months in weight, waist circumference, visceral fat, percent body fat, systolic blood pressure and fasting plasma glucose among both overweight and obese grade I respondents. Significant difference was also observed among overweight case and control respondents in total cholesterol, high density lipoprotein, low density lipoprotein, total lipids, non-HDL cholesterol and cholesterol HDL ratio. Inspite of these, significant difference was also noticed among overweight respondents in TNF-alpha and among obese grade I in hs-CRP and adiponectin between case and control group. Significant difference was also observed between case and control group of overweight and obese grade I respondents in fat, carbohydrate, energy, calcium and dairy calcium intake after 6 months of intervention. Therefore, it seems reasonable to argue that dietary management via hypocaloric diet suggested with dairy food products and increased physical activity may retard the growing incidence of overweight and obesity in future.